Docampo-Simon et al Int J Dermatol 2024 ➜ First published: 03 March 2024 – DOI: 10.1111/ijd.17100 Spanish investigators delineate based on a small case series psoriasis dermatitis, a common ambiguous phenotype of early forms of both psoriasis and atopic dermatitis in children; this phenotype was already well recognized in infants, but this study adds arguments for a later presentation in childhood.
The 80th anniversary of atopic dermatitis in the Annals of Allergy 2024 ➜ March 2024 – DOI: 10.1016/j.anai.2023.03.019 Leung underlines that understanding the science of skin inflammation has accelerated the identification of multiple therapeutic targets for the treatment of atopic dermatitis, but that the beginning was rather slow. From 1993 to 1996, IL-4 and IL-13 were identified in atopic dermatitis skin by his team, but it took near 25 years before dupilumab was introduced into clinical medicine.
Ochayon et al, Science Immunol 2024 ➜ DOI: 10.1126/sciimmunol.add3085 Progressive accumulation of hyperinflammatory NKG2Dlow NK cells defines an endotype of severe AD associated with allergen sensitivity, suggesting that NK cell dysregulation in AD potentially contributes to atopic march. This study points to a possible pathogenic contributions of NK cell cytokine production to skin barrier disruption and development of allergic comorbidities in this severe AD patient population.
Lunjani et al, Front Allergy, 2024 ➜ DOI: 10.3389/falgy.2023.1203304 Lunjani et al wrote a nice review on AD on African ancestry black skin individuals.
Berdyshev et al, JACI 2024 ➜ DOI: 10.1016/j.jaci.2024.02.014 Stratum corneum biomarkers are interesting in predicting the risk of AD and food allergy. Increased expression of S100A8.9 on a skin swab of the antecubital fossa in infants at 8 weeks of age was found predictive of the development and persistence of AD in the first year of life.
Stamatas et al, JACI 2024 ➜ DOI: 10.1016/j.jaci.2024.02.018 Lipid and cytokine levels in the stratum corneum at the age of 2 months was found to selectively predict with high probability the future onset of food allergy up to the age of 2 years.
