Release of the 4th Davos declaration on AD and Allergy ➜ DOI: 10.1111/all.16247 The 2022 Forum is now published with its usual “Declaration” signed by all participants. Besides the mounting burden of AD, attributed to significant environmental and lifestyle changes, the Forum acknowledged the progress in understanding AD and in developing targeted therapies but recognized a gap in translating these innovations into clinical practice. Emphasis was placed on the need for enhanced awareness, education, and stakeholder engagement to address this gap effectively and to consider environmental and lifestyle factors in a comprehensive disease management strategy.
AD itch circadian rhythm ➜ DOI: 10.2340/actadv.v104.35427 This Chinese study describes the circadian rhythm characteristics of itching in 241 adult patients with AD. Itch in adult patients with AD occurred most frequently and with the greatest severity between 20:00 and 00:00, and the least number of patients experienced itching between 04:00 and 08:00. This study lays a foundation for adapted chronotherapy.
Extended Half‑life Antibodies ➜ DOI: 10.1007/s13555-024-01253-6 Extended half-life antibodies represent a promising advancement for the management of immune-mediated inflammatory diseases, including AD. These antibodies, engineered for prolonged circulation and reduced dosing frequency, offering potential for less frequent administration while maintaining efficacy. Currently, two such agents are in phase 2 trials. APG777, targeting interleukin-13 (IL-13), and IMG-007, targeting OX40 receptor.
Breast milk-derived arachidonic acid (AA)-induced infant gut dysbiosis and onset of atopic dermatitis ➜ DOI: 10.1136/gutjnl-2024-332407 This study is based on clinical observations of a possible detrimental effect of breastfeeding on the onset of AD which led to the hypothesis that breast milk with varying compositions could affect the gut microbial community in infants. The authors show that breast milk-derived AA induces gut microbiota dysbiosis in infants with AD and affects microbial pathways. Using a mouse model, they show that AA can induce an imbalance in the CD4/CD8 cell ratio, increase the area of skin lesions and the proportion of peripheral circulating Th2 cells, promote serum IgE secretion and catalyze prostaglandin and leukotriene biosynthesis.
The Clinical, Mechanistic, and Social Impacts of Air Pollution on Atopic Dermatitis ➜ DOI: 10.1016/j.jaci.2024.07.027 This review adopts a novel angle of attack and discusses the weight of several factors known to contribute to the pathophysiology of AD, criticizing genetic determinist views of either innate barrier defects leading to inflammation or innate inflammation eroding skin barrier function. Concerning Staphylococcus aureus, the authors consider that a highly contagious microorganism is unlikely to be the primary etiology of a non-communicable disease. Concerning the skin or gut dysbiosis as potentially targetable drivers of AD, they suppose the induction by an environmental factor which needs to be first identified. So, their main objective is to review evidence supporting the environmental hypothesis of AD etiology and its social impacts and detail the molecular mechanisms of each AD-relevant toxin.
