Season of birth shapes human milk microbiome ➜ DOI: 10.1111/all.16469 In this Australian study, the season of infant birth emerged as the strongest determinant of the microbiome community structure with impacts on five of the most abundant taxa. This seasonal effect is not correlated with a bad taxon more prevalent in winter where AD is more common. The milk microbiome also varied according to the type of maternal allergic disease (allergic rhinitis, asthma, atopic dermatitis, and food allergy). Interestingly, infant formula exposure reduced the relative abundance of several typical oral taxa in milk.
Can persistence of AD be explained by early life diet? ➜ DOI: 10.1016/j.jaci.2024.10.036 Using data from over 600,000 Korean children diagnosed with AD before age 7, researchers identified 21.6% with persistent AD at ages 7–9. Exclusive breastfeeding and delayed complementary feeding (beyond 6 months) were linked to higher odds of persistent AD, supporting the current view that limiting prolonged breastfeeding and introducing early complementary feeding may reduce AD risk. Obesity, picky eating habits, irregular meal patterns, and high consumption of sugary drinks were associated with increased AD persistence. Children transitioning to more diverse and regular eating habits had lower odds of persistent AD, suggesting a protective role of early healthy eating habits.
Should we pay more attention to Type 1 allergy to sweat in AD patients? ➜ DOI: 10.1016/j.alit.2024.11.004 Sweat-induced type I allergic reactions play a role in the pathogenesis of atopic dermatitis (AD) by exacerbating itch. MGL_1304, a protein from Malassezia globosa, is identified as the primary allergen. This Japanese study utilized the histamine release test against semi-purified sweat antigen (QR) as a diagnostic benchmark. The authors highlight the diagnostic utility of anti-MGL_1304 IgE detection using the ImmunoCAP system. This approach offers a simple, accurate, and specific tool for identifying sweat allergy, outperforming conventional assays that measure anti-Malassezia antigen IgE. and could become a valuable tool for diagnosing sweat allergy in AD clinical settings, an approach which seems rare outside Japan.
Upadacitinib rhabdomyolysis in a crossfit addict: which practical teachings? ➜ DOI: 10.1093/bjd/ljae485 The authors express concern over the recommendation in a recent guide by the International Eczema Council to only measure creatine kinase (CPK) levels in patients exhibiting symptoms like muscle weakness or myalgia, as elevated CPK levels are frequently seen with JAKi use but are often asymptomatic and associated with exercise. The case presented involves a 30-year-old male who developed rhabdomyolysis after engaging in intense physical activity during upadacitinib treatment. The letter suggest individualized monitoring of CPK levels for patients involved in high-intensity physical activities and recommend monitoring CPK levels in such patients rather than waiting for symptoms to manifest.
VZV in AD hospitalized patients: arguments for a better prevention ➜ DOI: 10.2340/actadv.v104.42326 Using the Danish health registry data from 1979–2017, 46,875 AD patients were analyzed for concomitant VZV infection during hospital admissions. Hospitalizations for varicella occurred mostly in young children at a rate of 16.2 per 100,000 person-years. Complications, mostly bacterial superinfections occurred in 47.1% of cases, and the median hospital stay was 3 days. For zoster hospitalizations of mostly adults occurred at a rate of 7.2 per 100,000 person-years with 22.3% of complications, and the median hospital stay was 6.5 days. The study highlights the substantial burden of VZV infections in AD patients, advocating for the varicella vaccine in the pediatric AD group. For moderate-to-severe adult AD patients, the zoster subunit vaccine should be considered.
