Why Infantile AD Gets Missed: Cracking the Code of Early AD Diagnosis ➜ DOI: 10.1111/1346-8138.70052 A large Japanese cohort study identifies key barriers to accurately diagnosing infantile atopic dermatitis (AD). Findings reveal frequent underdiagnosis, often due to transient eczematous eruptions and overlapping conditions in early infancy. Clinical uncertainty is heightened by atypical presentations and rapidly evolving skin features during the first months of life. The study emphasizes the need for clearer diagnostic criteria and improved clinician training for infants. Reluctance to inform parents/caregivers of an AD diagnosis was high and mostly due to anticipation of parental shock. Early, accurate recognition of AD is essential to optimize treatment and prevent long-term disease progression.
Cesarean Birth and Infantile AD: A Giant Study with a Surprising Null Result ➜ DOI: 10.1038/s41598-025-23252-z A nationwide Japanese birth cohort of 74,639 infants examined whether cesarean delivery increases the risk of wheezing, eczema, asthma, or atopic dermatitis at 1 year of age. After adjusting for extensive perinatal, socioeconomic, and postnatal factors, no associations were found between cesarean birth and any allergic outcome. Elective and emergency cesarean sections likewise showed no increased risk, with emergency cesareans even showing a slight decrease in reported eczema. These robust findings challenge prior assumptions linking delivery mode to early allergic disease. The authors conclude that cesarean delivery does not contribute meaningfully to AD or asthma development in infancy.
Decyl Glucoside and Preservatives: Unveiling Specific Contact Allergy Risks in Atopic Dermatitis ➜ DOI: 10.1111/cod.70036 This retrospective analysis of 7,936 patch-tested patients reveals that while atopic dermatitis (AD) is not associated with a generally higher risk of contact allergy to preservatives, specific perpetrators exist. AD patients demonstrated significantly higher sensitization rates to 2-bromo-2-nitropropane-1,3-diol and the emulsifier decyl glucoside (14.3% vs 3.1%) compared to non-atopic patients. Conversely, allergy to the industrial preservative benzisothiazolinone was significantly more prevalent in the non-AD population (15.4% vs 8.1%). The authors emphasize the importance of vigilance toward decyl glucoside, a surfactant frequently found in “sensitive skin” products, given its high prevalence among AD patients.
Pediatric Cellulitis caused by Atopic Dermatitis, a significant issue ➜ DOI: 10.3389/fped.2025.1675978 A nationwide analysis of 15,497 pediatric hospitalizations in Spain reveals that cellulitis presentation evolves significantly with age, shifting from facial dominance in toddlers (40.3%) to the extremities in adolescents (49.7%). While mortality remains negligible (0.1%), the cumulative healthcare burden is substantial, totaling €54.7 million, with the highest costs incurred by the 0-4 age group. Trauma and open wounds were identified as the primary predisposing factors (13.5%), particularly in older children, while atopic dermatitis accounted for 3.1% of cases.
To Bathe or Not to Bathe frequently? Citizen science answers ➜ DOI: 10.1093/bjd/ljaf417 This “citizen science” co-produced RCT involving 438 participants <16y compared the impact of weekly (1-2 times) versus daily bathing on AD severity over four weeks. The study found no clinically meaningful difference in primary symptom scores (POEM) between the two groups, nor in secondary measures like itch intensity or quality of life. These findings suggest that neither regimen is superior, effectively debunking the need for rigid bathing protocols for symptom control. Consequently, the authors conclude that patients should feel empowered to choose a washing routine based on personal preference rather than therapeutic dogma.nce therapeutic efficacy, and offer patients an affordable, safe, and effective treatment option.
