Vernal keratoconjunctivitis (VKC) and AD ➜ DOI: 10.2147/OPTH.S472826 The importance of ophthalmological co-morbidities of AD was recently highlighted because of the large literature on dupilumab and ocular surface disorders, but several other aspects are currently neglected. VKC is a refractory ocular allergic disorder that mainly affects boys, and long-term follow-up has been rarely reported. The Department of Ophthalmology of Fukuoka University Hospital reports in a longitudinal study a close association of VKC with AD. AD was related to worse outcome with a high sensitivity and specificity.
Humans are unreliable models of mouse disease ➜ DOI: 10.1016/j.cell.2024.08.006 This is an account of the out of the box thinking of Brian Kim who, after designing a nerve targeted JAK1 gain of function mouse, persisted when he got wrongly a germline gain of function JAK1 mouse model (the mouse model of the human disease described by Stuart Sturvey and his group where JAK1 inhibition was shown to treat intractable AD associated pruritus), and went showing unexpectedly that JAK1 overexpression in the lung limits inflammation and asthma. Worth reading for those interested in epistemology, suggesting that writing hypothesis-driven grants if good to get money needs to be transcended in real life to reach the discovery level.
Childhood obesity and AD in young children ➜ DOI: 10.1016/j.jid.2024.01.037 Korean investigators looked at the associations between body mass index or body mass indexchanges and the development of alopecia areata, AD and psoriasis by analyzing a longitudinal cohort of 2 million Korean young children from 2009 to 2020. With the reservation that AD is far more frequent than AA and psoriasis under the age of 4, and that mistakes in diagnosis could occur in the databases, the data revealed only for AD a significant correlation between BMI increases from 30-36 months to 42-48 months, 54-60 months, and 66-71 months and an elevated risk of AD. However, a decrease in BMI was associated with reduced risks of AD. The authors suggest that managing weight changes and regulating body weight during childhood may influence the development of subsequent AD.
Diet prevention of allergic diseases ➜ DOI: 10.1111/all.16292 The originality of this study is to have performed in a prebirth cohort a combined study of childhood diet diversity with an offspring allergy-linked maternal diet survey during pregnancy. With the reservation that maternal and infant diet were self-reported, the novel finding is that the combination of a preventive maternal diet during pregnancy and an appropriate infant diet diversity at 12 months lower the risk of allergic disease in childhood.
Mouse models for atopic march ➜ DOI: 10.1093/intimm/dxae053 This review paper is a useful resource for comparing existing mouse models designed to examine the debated atopic march concept. The authors have a strong experience in mouse models and have tabulated the existing models in addition to a critical update of the concept.
